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KMID : 0378019920350070025
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New Medical Journal
1992 Volume.35 No. 7 p.25 ~ p.36
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PATHOGENESIS OF "STRESS DISEASE"
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Park Syuk-Ryun
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Abstract
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The term stress has been defined in several different ways. Sometimes the term is applied to stimuli or events in our environment that make emotional and physical demands on us, and sometimes it is applied. to our emotional and physical reactions to such stimuli. In this study, I will refer to the psychic environmental stimuli or events as stressors, and to the subsequent mental tension as stress, and to the subsequent biological reactions as stress reaction, and to the subsequent homeostatic derailment (illness) as stress disease.
In many stressful situations, the body´s responses can improve our performance. But when stress is encountered continually, the body´s-reactions are more likely to be harmful than helpful to us.
Recently I have hit upon "Stress Disease" by way of my unique research on the contemporary diseases"). They are essential hypertension and diabetes mellitus. Needless to say, these two diseases can be said to be the archenemies of modern man´s, longevity.
It is true that .the development of modem civilization has endowed us with a vast of material comforts, but on the other hand, these benefits of modern civilization have brought us an excessive mental stimulus and tension which ultimately result in our having harmful stresses about us.
Today we see that a large amount of mental stresses are brought on to. the humanity by such modern problems as too rapid a development of science, civilization and industrialization, the con centralization of- cities, population, explosions, economic difficulties, ideological absurdities, political injustices, environment;*i pollution, the complications of social life, the threats of war, hideous nuclear weapons, and domestic conflicts etc. As a result, modem man leads .a life as if driven by mental strain, daily cares and worries. In such times as these, our human organisms activate two axes of instinctive biological reactions by way of the general adaptive response which comprises defense reaction. fight reaction and flight reaction, to these stresses. Thus, our body comes to give birth to an abnormal condition in the areas of hemodynamics and metabolic process. The former leads to essential hypertension, while the latter to diabetes mellitus.
The two axes of instinctive biological reactions are as follows : 1) the cerebral cortex (frontal lobe)-limbic lobe-hypothalamus-adrenomedullary axis, 2) the cerebral .cortex-limbic lobehypothalamus-hypophysis-adrenocortical axis. Through the former, epinephrine and norepinephrine are discharged, which bring about hemodynamic changes and at the same time through the latter, aldosterone and glucocorticoids are emitted, which cause metabolic
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